Causes and Treatments of Acute Hepatic Insufficiency and Chronic Hepatic Insufficiency

Inability of the liver to perform its functions both metabolic and synthetic is known as hepatic insufficiency. The hepatic insufficiency can be classified into acute hepatic insufficiency and chronic hepatic insufficiency. Two types of hepatic insufficiency are discussed in this blog.

Acute Hepatic Insufficiency

Loss of function of 80–90% of liver cells is associated with acute hepatic insufficiency. Physical exam, laboratory findings and patient history are used for the purpose of effective diagnosis of acute liver failure.

One of the common causes of the acute hepatic insufficiency is acetaminophen overdose. Other causes of the acute hepatic insufficiency are idiosyncratic reaction to medication. Furthermore, the acute hepatic insufficiency can be caused due to excessive alcohol consumption.  Viral hepatitis, such as hepatitis A or B, can cause acute hepatic insufficiency.


As per the recent studies, it was reported that the acute hepatic insufficiency can be caused by acute fatty liver of pregnancy. Furthermore, the acute hepatic insufficiency can be caused by idiopathic. Furthermore, Wilson’s disease can also cause acute hepatic insufficiency.

Patients suffering from the acute hepatic insufficiency are managed in the intense care unit as they often involve in the rapid deterioration of mental status. As acute hepatic insufficiency is associated with possibility of rapid progression, hence it is always critical for make early consultation with excellent transportation facility.

Low systemic vascular resistance and increased cardiac output are associated with acute hepatic insufficiency. Catheterization of pulmonary artery of should be done in cases of cardiovascular complications. Acute Hepatic insufficiencies are associated with pulmonary edema and pulmonary infections.

As per the recent study conducted, it was reported that the instant survival rate of the patient suffering from the acute hepatic insufficiency is now around 40% at some of the well-known and reputed hospitals in Delhi.

Acute hepatic insufficiency patients with grade I-II encephalopathy should be transferred to transplantation facilities and lists them for Liver Transplant in Delhi.

Chronic Hepatic Insufficiency

Progressive destruction and regeneration of the liver parenchyma is known as chronic liver disease, which results in cirrhosis and fibrosis.

Hepatitis B and Hepatitis C are considered to important factors causing chronic hepatic insufficiency. Moreover, Alcoholic liver disease can cause chronic hepatic insufficiency.

Non-alcoholic fatty liver disease and Haemochromatosis can also cause the chronic hepatic insufficiency. Right heart failure and autoimmune diseases can also cause chronic hepatic insufficiency.

Based on the cause of the chronic hepatic insufficiency, the treatment can be carried out through corticosteroids and interferon. Other medications used for the treatment of chronic hepatic insufficiency are antiviral and bile acids.

Apart from medication, the patients might require liver transplantation in cases of last stage of chronic hepatic insufficiency.

Liver Transplant Hospital in Delhi often indicates patients suffering from the acute hepatic insufficiency with liver transplantation with success rate of 56–90%. Better survival rates were attained through with better critical care and trend towards more benign causes, in addition to the liver transplantation procedures.


Types of Liver Diseases and Treatment of Liver Diseases

Liver functions to metabolize the nutrients that are absorbed by the intestine. One of the important functions of liver is to store nutrients.  Furthermore, liver detoxify blood by removing medications. Liver play important role in removing alcohol and potentially for detoxification of blood. Potentially harmfully chemical is also removed by the liver, for detoxification of blood efficiently.

Types of Liver Diseases

The damage to liver that affects its functionality is known as hepatic disease or commonly known as liver disease. Some of the common types of liver diseases in Delhi are Fascioliasis and Hepatitis.  Caused by a liver fluke of the fasciola genus, the infection of Fascioliasis is a parasitic injection. Viral hepatitis is inflammation of liver that is effectively caused by different viruses.

Alcoholic hepatitis is inflammation of liver that is caused by some liver toxins. Furthermore, hepatitis can be used by the hereditary conditions and autoimmunity. The hepatitis caused by the autoimmunity is known as autoimmune hepatitis.

Non-alcoholic fatty liver disease is liver disease associated with metabolic syndrome and obesity. Hemochromatosis is hereditary condition that effectively causes damage of liver with accumulation of iron in the body. It is also associated with accumulation of Wilson’s diseases.

Alcohol overconsumption can cause alcoholic liver diseases. Besides this, alcohol overconsumption can also cause fatty liver disease. Cirrhosis and alcoholic hepatitis are also associated with alcohol overconsumption. Substance abuse can cause drug-induced or toxic liver diseases. Hepatic steatosis is another liver disease that is reversible condition, in which liver cells are accumulated by large vacuoles of triglyceride.

Transthyretin-related hereditary Amyloidosis is liver disease in that the liver effectively produces a mutated transthyretin protein.  The mutated transthyretin can produce cardiopathic effects and neurodegenerative effects on the liver. As per first among the best Liver Transplant Surgeon in Delhi, Transthyretin-related hereditary Amyloidosis can be curative treated with liver transplantation.

Autoimmune disease of the bile capillaries is primary biliary cirrhosis. Furthermore, primary liver cancer can effectively damage liver and affects their functionality.

Treatment of Liver Diseases:

In order to treat different types of liver diseases such as hepatitis, many viral medications can available in the market, which can be purchase on prescription provided by the doctors.  Autoimmune hepatitis can be managed by using steroid based drugs, for managing of the liver disease by slowing down the profession of the disease.

Hemochromatosis can be used to treat the liver diseases, by regularly removing a quantity of the blood from the vein in the iron overload conditions.

Primary biliary cirrhosis and hepatitis B/C are some of the diseases that can be effectively treated through liver transplantation. In end stage liver diseases, the treatment is replacement of the liver through liver transplant procedures conducted and supervised by experienced Liver Transplant Surgeon. Biliary Artesia and Wilson’s disease can lead to end state liver diseases that require liver transplantation for effective treatment. Liver Cancer can permanently damage liver without repair and hence liver transplantation is only solution.

Cause of Liver Failure and its Symptoms

Liver failure means that large part of the liver is not able to function normally and it has got damaged beyond repair. The liver failure can be life threatening disease. It never happens all of sudden but can happen gradually over the years. However, the acute liver failure can occur within a day or two and cannot be detected initially. There are many reasons for the failure of the liver. Some of these are due to the diseases like hepatitis B and C , consumption of alcohol for long duration , cirrhosis and some inherited disease where a person absorb too much iron. Malnutrition can also lead to liver failure.

The acute liver failure which can happen in couple of day , has different reasons and these may include overdose of some medicines like Tylenol , hepatitis B  C  or   A virus  specially in kids can causes the acute liver failure . The consumption of wild poisonous mushrooms and reaction to certain medication can also lead to acute liver failure.

Symptoms of the liver failure can also occur in other medical problem that is why; it is difficult to properly detect the liver failure accurately. The conditions like fatigue, nausea, diarrhea and loss of appetite can also happen with other medical common problems.  But as liver failure progresses, the symptoms may become more clear. These are jaundice, swallow abdomen, difficulty in sleeping, bleeding easily and mental confusion. Finally it can lead to coma.

Early detection plays an important role in the treatment of the liver failure. If detected early and caused by overdose of some medicines, then failure can be treated and reversed. In case of liver failure caused by virus, the virus symptoms are treated at hospitals. When virus is cured or treated the liver recovers on its own.   In the liver failure that is result of the long deterioration of liver, the efforts are made to save the remaining part of the liver that is functioning and normal.  When that is not possible, then the final step is the liver transplantations. Liver transplantation has Liver Transplant Surgeon     high rate of success these days.

The only way to prevent the liver failure is to decrease the risk of developing liver diseases and infection. The efforts should be to limit the risk of cirrhosis and hepatitis virus.   Some steps can be taken to prevent the risk of hepatitis like taking the injections, taking proper balanced diet, limit the use of alcohol, maintaining hygiene by washing hands before eating and after using bathroom or toilet.

Anyone who takes Tylenol Liver Transplant Hospital in Delhi   medicine must not take the alcohol.  There are other common practices, which should be followed by person normally for keeping diseases away. These are not sharing the used razors and toothbrushes. The proper care, in form of condom, must also be taken before establishing physical relations with a stranger. The person going for tattoos must ask for use of sterilized needles or equipments.