Inability of the liver to perform its functions both metabolic and synthetic is known as hepatic insufficiency. The hepatic insufficiency can be classified into acute hepatic insufficiency and chronic hepatic insufficiency. Two types of hepatic insufficiency are discussed in this blog.
Acute Hepatic Insufficiency
Loss of function of 80–90% of liver cells is associated with acute hepatic insufficiency. Physical exam, laboratory findings and patient history are used for the purpose of effective diagnosis of acute liver failure.
One of the common causes of the acute hepatic insufficiency is acetaminophen overdose. Other causes of the acute hepatic insufficiency are idiosyncratic reaction to medication. Furthermore, the acute hepatic insufficiency can be caused due to excessive alcohol consumption. Viral hepatitis, such as hepatitis A or B, can cause acute hepatic insufficiency.
As per the recent studies, it was reported that the acute hepatic insufficiency can be caused by acute fatty liver of pregnancy. Furthermore, the acute hepatic insufficiency can be caused by idiopathic. Furthermore, Wilson’s disease can also cause acute hepatic insufficiency.
Patients suffering from the acute hepatic insufficiency are managed in the intense care unit as they often involve in the rapid deterioration of mental status. As acute hepatic insufficiency is associated with possibility of rapid progression, hence it is always critical for make early consultation with excellent transportation facility.
Low systemic vascular resistance and increased cardiac output are associated with acute hepatic insufficiency. Catheterization of pulmonary artery of should be done in cases of cardiovascular complications. Acute Hepatic insufficiencies are associated with pulmonary edema and pulmonary infections.
As per the recent study conducted, it was reported that the instant survival rate of the patient suffering from the acute hepatic insufficiency is now around 40% at some of the well-known and reputed hospitals in Delhi.
Acute hepatic insufficiency patients with grade I-II encephalopathy should be transferred to transplantation facilities and lists them for Liver Transplant in Delhi.
Chronic Hepatic Insufficiency
Progressive destruction and regeneration of the liver parenchyma is known as chronic liver disease, which results in cirrhosis and fibrosis.
Hepatitis B and Hepatitis C are considered to important factors causing chronic hepatic insufficiency. Moreover, Alcoholic liver disease can cause chronic hepatic insufficiency.
Non-alcoholic fatty liver disease and Haemochromatosis can also cause the chronic hepatic insufficiency. Right heart failure and autoimmune diseases can also cause chronic hepatic insufficiency.
Based on the cause of the chronic hepatic insufficiency, the treatment can be carried out through corticosteroids and interferon. Other medications used for the treatment of chronic hepatic insufficiency are antiviral and bile acids.
Apart from medication, the patients might require liver transplantation in cases of last stage of chronic hepatic insufficiency.
Liver Transplant Hospital in Delhi often indicates patients suffering from the acute hepatic insufficiency with liver transplantation with success rate of 56–90%. Better survival rates were attained through with better critical care and trend towards more benign causes, in addition to the liver transplantation procedures.